Extracellular Vesicles and Autophagy in Osteoarthritis
Joint Authors
Guo, Weimin
Peng, Jiang
Wang, Ai-Yuan
Zhang, Li
Xu, Wen-Jing
Guo, Quan-Yi
Wang, Yu
Shibi, Lu
Huang, Jingxiang
Yuan, Zhiguo
Sui, Xiang
Gao, Tianyang
Chen, Mingxue
Zhang, Yu
Wang, Mingjie
Li, Penghao
Zhang, Xifeng
Liu, Shuyun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteoarthritis (OA) is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone.
There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism.
However, the etiology and pathogenesis of OA remain unclear and need urgent clarification to guide the early diagnosis and treatment of OA.
Extracellular vesicles (EVs) are small membrane-linking particles that are released from cells.
In recent decades, several special biological properties have been found in EV, especially in terms of cartilage.
Autophagy plays a critical role in the regulation of cellular homeostasis.
Likewise, more and more research has gradually focused on the effect of autophagy on chondrocyte proliferation and function in OA.
The synthesis and release of EV are closely associated with autophagy.
At the same time, both EV and autophagy play a role in OA development.
Based on the mechanism of EV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of EV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies.
American Psychological Association (APA)
Gao, Tianyang& Guo, Weimin& Chen, Mingxue& Huang, Jingxiang& Yuan, Zhiguo& Zhang, Yu…[et al.]. 2016. Extracellular Vesicles and Autophagy in Osteoarthritis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097069
Modern Language Association (MLA)
Gao, Tianyang…[et al.]. Extracellular Vesicles and Autophagy in Osteoarthritis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097069
American Medical Association (AMA)
Gao, Tianyang& Guo, Weimin& Chen, Mingxue& Huang, Jingxiang& Yuan, Zhiguo& Zhang, Yu…[et al.]. Extracellular Vesicles and Autophagy in Osteoarthritis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097069