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HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia
Joint Authors
Gashnikova, Natalya M.
Astakhova, Ekaterina M.
Gashnikova, Mariya P.
Bocharov, Evgeniy F.
Petrova, Svetlana V.
Pun’ko, Olga A.
Popkov, Alexander V.
Totmenin, Aleksey V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Introduction.
Specific molecular epidemic features of HIV infection in Tyumen Oblast (TO), Russia, were studied.
Methods.
The genome sequences encoding HIV-1 protease-reverse transcriptase, integrase, and major envelope protein were examined for 72 HIV-1 specimens isolated from the TO resident infected in 2000–2015.
Results.
The recorded prevalence of HIV-1 subtype A (A1) is 93.1%; HIV-1 subtype B continues to circulate in MSM risk group (1.4%).
Solitary instances of HIV-1 recombinant forms, CRF63_02A1 (1.4%) and CRF03_AB (1.4%), were detected as well as two cases of HIV-1 URF63_A1 (2.8%).
Phylogenetic analysis showed no HIV-1 clustering according to the duration of infection and risk groups but revealed different epidemic networks confirming that HIV infection spread within local epidemic foci.
A high incidence of CXCR4-tropic HIV-1 variants and a higher rate of secondary mutations influencing the virus fitness (K20R, L10V, and I) are observed among the virus specimens isolated from newly infected individuals.
Conclusions.
The current HIV-1 epidemic in TO develops within the local epidemic networks.
Similar to the previous period, HIV-1 subtype A is predominant in TO with sporadic cases of importation of HIV-1 recombinant forms circulating in adjacent areas.
American Psychological Association (APA)
Gashnikova, Natalya M.& Astakhova, Ekaterina M.& Gashnikova, Mariya P.& Bocharov, Evgeniy F.& Petrova, Svetlana V.& Pun’ko, Olga A.…[et al.]. 2016. HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097086
Modern Language Association (MLA)
Gashnikova, Natalya M.…[et al.]. HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097086
American Medical Association (AMA)
Gashnikova, Natalya M.& Astakhova, Ekaterina M.& Gashnikova, Mariya P.& Bocharov, Evgeniy F.& Petrova, Svetlana V.& Pun’ko, Olga A.…[et al.]. HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097086