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Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model
Joint Authors
Song, Dan
Zhong, Yun
Qian, Chunfeng
Zou, Qinyan
Ou, Jian
Shi, Yichao
Gao, Liang
Wang, Gaigai
Liu, Zhenxing
Li, Haibo
Ding, Hailei
Wu, Huihua
Wang, Fuxin
Wang, Jing
Li, Hong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Premature ovarian failure (POF) is one of the most common causes of infertility in women.
In our present study, we established cyclophosphamide- (CTX-) induced POF rat model and elucidated its effect on ovarian function.
We detected the serum estrogen, follicle stimulating hormone, and anti-Müllerian hormone of mice models by ELISA and evaluated their folliculogenesis by histopathology examination.
Our study revealed that CTX administration could severely disturb hormone secretion and influence folliculogenesis in rat.
This study also detected ovarian cells apoptosis by deoxy-UTP-digoxigenin nick end labeling (TUNEL) and demonstrated marked ovarian cells apoptosis in rat models following CTX administration.
In order to explore the potential of human umbilical cord mesenchymal stem cells (UCMSCs) in POF treatment, the above indexes were used to evaluate ovarian function.
We found that human UCMSCs transplantation recovered disturbed hormone secretion and folliculogenesis in POF rat, in addition to reduced ovarian cell apoptosis.
We also tracked transplanted UCMSCs in ovaries by fluorescence in situ hybridization (FISH).
The results manifested that the transplanted human UCMSCs could reside in ovarian tissues and could survive for a comparatively long time without obvious proliferation.
Our present study provides new insights into the great clinical potential of human UCMSCs in POF treatment.
American Psychological Association (APA)
Song, Dan& Zhong, Yun& Qian, Chunfeng& Zou, Qinyan& Ou, Jian& Shi, Yichao…[et al.]. 2016. Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097093
Modern Language Association (MLA)
Song, Dan…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097093
American Medical Association (AMA)
Song, Dan& Zhong, Yun& Qian, Chunfeng& Zou, Qinyan& Ou, Jian& Shi, Yichao…[et al.]. Human Umbilical Cord Mesenchymal Stem Cells Therapy in Cyclophosphamide-Induced Premature Ovarian Failure Rat Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097093