Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors
Joint Authors
Wu, Semon
Wu, Chang-Chieh
Tsai, Fu-Ming
Chen, Mao-Liang
Lee, Ming-Cheng
Tsai, Tzung-Chieh
Wang, Lu-Kai
Wang, Chun-Hua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Antipsychotic drugs (APDs) used to treat clinical psychotic syndromes cause a variety of blood dyscrasias.
APDs suppress the aggregation of platelets; however, the underlying mechanism remains unknown.
We first analyzed platelet aggregation and clot formation in platelets treated with APDs, risperidone, clozapine, or haloperidol, using an aggregometer and rotational thromboelastometry (ROTEM).
Our data indicated that platelet aggregation was inhibited, that clot formation time was increased, and that clot firmness was decreased in platelets pretreated with APDs.
We also examined the role two major adenosine diphosphate (ADP) receptors, P2Y1 and P2Y12, play in ADP-mediated platelet activation and APD-mediated suppression of platelet aggregation.
Our results show that P2Y1 receptor stimulation with ADP-induced calcium influx was inhibited by APDs in human and rats’ platelets, as assessed by in vitro or ex vivo approach, respectively.
In contrast, APDs, risperidone and clozapine, alleviated P2Y12-mediated cAMP suppression, and the release of thromboxane A2 and arachidonic acid by activated platelets decreased after APD treatment in human and rats’ platelets.
Our data demonstrate that each APD tested significantly suppressed platelet aggregation via different mechanisms.
American Psychological Association (APA)
Wu, Chang-Chieh& Tsai, Fu-Ming& Chen, Mao-Liang& Wu, Semon& Lee, Ming-Cheng& Tsai, Tzung-Chieh…[et al.]. 2016. Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097097
Modern Language Association (MLA)
Wu, Chang-Chieh…[et al.]. Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097097
American Medical Association (AMA)
Wu, Chang-Chieh& Tsai, Fu-Ming& Chen, Mao-Liang& Wu, Semon& Lee, Ming-Cheng& Tsai, Tzung-Chieh…[et al.]. Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097097