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Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity
Joint Authors
Sivanesan, Saravanadevi
Naoghare, Pravin K.
Kannan, Krishnamurthi
Tarale, Prashant
Chakrabarti, Tapan
Bafana, Amit
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Manganese is a vital nutrient and is maintained at an optimal level (2.5–5 mg/day) in human body.
Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson’s disease.
Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity.
Oxidative stress has a potential to alter the epigenetic mechanism of gene regulation.
Epigenetic insight of manganese neurotoxicity in context of its correlation with the development of parkinsonism is poorly understood.
Parkinson’s disease is characterized by the α-synuclein aggregation in the form of Lewy bodies in neuronal cells.
Recent findings illustrate that manganese can cause overexpression of α-synuclein.
α-Synuclein acts epigenetically via interaction with histone proteins in regulating apoptosis.
α-Synuclein also causes global DNA hypomethylation through sequestration of DNA methyltransferase in cytoplasm.
An individual genetic difference may also have an influence on epigenetic susceptibility to manganese neurotoxicity and the development of Parkinson’s disease.
This review presents the current state of findings in relation to role of epigenetic mechanism in manganese induced neurotoxicity, with a special emphasis on the development of Parkinson’s disease.
American Psychological Association (APA)
Tarale, Prashant& Chakrabarti, Tapan& Sivanesan, Saravanadevi& Naoghare, Pravin K.& Bafana, Amit& Kannan, Krishnamurthi. 2016. Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity. BioMed Research International،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1097099
Modern Language Association (MLA)
Tarale, Prashant…[et al.]. Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity. BioMed Research International No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1097099
American Medical Association (AMA)
Tarale, Prashant& Chakrabarti, Tapan& Sivanesan, Saravanadevi& Naoghare, Pravin K.& Bafana, Amit& Kannan, Krishnamurthi. Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1097099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097099