Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis
Joint Authors
Gu, Wen
Jiang, Chunping
Ni, Qing
Ji, Anlai
Wu, Junhua
Luo, Dongjun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
QC4 is the derivative of rosin’s main components dehydroabietic acid (DHA).
We investigated the cytotoxic effect of QC4 on gastric cancer cells and revealed the mechanisms beneath the induction of cell death.
Methods.
The cytotoxic effect of QC4 on gastric cancer cells was evaluated by CCK-8 assay and flow cytometry.
The underlying mechanisms were tested by administration of cell death related inhibitors and detection of apoptotic and oncosis related proteins.
Cytomembrane integrity and organelles damage were confirmed by lactate dehydrogenase (LDH) leakage assay, mitochondrial function test, and cytosolic free Ca2+ concentration detection.
Results.
QC4 inhibited cell proliferation dose- and time-dependently and destroyed cell membrane integrity, activated calpain-1 autolysis, and induced apoptotic protein cleavage in gastric cancer cells.
The detection of decreased ATP and mitochondrial membrane potential, ROS accumulation, and cytosolic free Ca2+ elevation confirmed organelles damage in QC4-treated gastric cancer cells.
Conclusions.
DHA derivative QC4 induced the damage of cytomembrane and organelles which finally lead to oncosis and apoptosis in gastric cancer cells.
Therefore, as a derivative of plant derived small molecule DHA, QC4 might become a promising agent in gastric cancer therapy.
American Psychological Association (APA)
Luo, Dongjun& Ni, Qing& Ji, Anlai& Gu, Wen& Wu, Junhua& Jiang, Chunping. 2016. Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097108
Modern Language Association (MLA)
Luo, Dongjun…[et al.]. Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097108
American Medical Association (AMA)
Luo, Dongjun& Ni, Qing& Ji, Anlai& Gu, Wen& Wu, Junhua& Jiang, Chunping. Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097108