An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials
Joint Authors
Yu, Tinghe
Zhang, Ying
Luo, Li
Zheng, Xueling
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A nude mouse received subcutaneous injection of human ovarian cancer cells HO-8910PM to form a tumor, and then the tumor fragment was surgically transplanted to the ovary of a recipient mouse to establish an orthotopic cancer model.
Tumors occurred in 100% of animals.
A mouse displayed an ovarian mass, ascites, intraperitoneal spread, and lung metastasis at natural death.
The mean survival time was 34.1 ± 1 7 .
2 days, with median survival time of 28.5 days.
The findings indicated that the present mouse model can reflect the biological behavior of advanced human ovarian cancers.
This in vivo model can be used to explore therapeutic means against chemoresistance and metastasis, and an effective treatment would prolong the survival time.
American Psychological Association (APA)
Zhang, Ying& Luo, Li& Zheng, Xueling& Yu, Tinghe. 2016. An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials. BioMed Research International،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1097112
Modern Language Association (MLA)
Zhang, Ying…[et al.]. An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials. BioMed Research International No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1097112
American Medical Association (AMA)
Zhang, Ying& Luo, Li& Zheng, Xueling& Yu, Tinghe. An Advanced Orthotopic Ovarian Cancer Model in Mice for Therapeutic Trials. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1097112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097112