Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis
Joint Authors
Saneyasu, Takaoki
Akhtar, Riaz
Sakai, Takao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression.
However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood.
Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels.
Extracellular matrix (ECM) influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases.
In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis.
American Psychological Association (APA)
Saneyasu, Takaoki& Akhtar, Riaz& Sakai, Takao. 2016. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097129
Modern Language Association (MLA)
Saneyasu, Takaoki…[et al.]. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097129
American Medical Association (AMA)
Saneyasu, Takaoki& Akhtar, Riaz& Sakai, Takao. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097129