Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

Joint Authors

Saneyasu, Takaoki
Akhtar, Riaz
Sakai, Takao

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-10-09

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression.

However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood.

Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels.

Extracellular matrix (ECM) influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases.

In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis.

American Psychological Association (APA)

Saneyasu, Takaoki& Akhtar, Riaz& Sakai, Takao. 2016. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097129

Modern Language Association (MLA)

Saneyasu, Takaoki…[et al.]. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097129

American Medical Association (AMA)

Saneyasu, Takaoki& Akhtar, Riaz& Sakai, Takao. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097129

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1097129