Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study
Joint Authors
Wang, Liping
Hsu, Hung-Yao
Li, Xu
Xian, Cory J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Bone cells are deformed according to mechanical stimulation they receive and their mechanical characteristics.
However, how osteoblasts are affected by mechanical vibration frequency and acceleration amplitude remains unclear.
By developing 3D osteoblast finite element (FE) models, this study investigated the effect of cell shapes on vibration characteristics and effect of acceleration (vibration intensity) on vibrational responses of cultured osteoblasts.
Firstly, the developed FE models predicted natural frequencies of osteoblasts within 6.85–48.69 Hz.
Then, three different levels of acceleration of base excitation were selected (0.5, 1, and 2 g) to simulate vibrational responses, and acceleration of base excitation was found to have no influence on natural frequencies of osteoblasts.
However, vibration response values of displacement, stress, and strain increased with the increase of acceleration.
Finally, stress and stress distributions of osteoblast models under 0.5 g acceleration in Z-direction were investigated further.
It was revealed that resonance frequencies can be a monotonic function of cell height or bottom area when cell volumes and material properties were assumed as constants.
These findings will be useful in understanding how forces are transferred and influence osteoblast mechanical responses during vibrations and in providing guidance for cell culture and external vibration loading in experimental and clinical osteogenesis studies.
American Psychological Association (APA)
Wang, Liping& Hsu, Hung-Yao& Li, Xu& Xian, Cory J.. 2016. Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1097144
Modern Language Association (MLA)
Wang, Liping…[et al.]. Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study. BioMed Research International No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1097144
American Medical Association (AMA)
Wang, Liping& Hsu, Hung-Yao& Li, Xu& Xian, Cory J.. Effects of Frequency and Acceleration Amplitude on Osteoblast Mechanical Vibration Responses: A Finite Element Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1097144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097144