Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature
Joint Authors
Gundelly, Praveen
Suzuki, Yasuhiro
Ribes, Julie A.
Thornton, Alice
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rhodococcus equi is an unusual zoonotic pathogen that can cause life-threatening diseases in susceptible hosts.
Twelve patients with R.
equi infection in Kentucky were compared to 137 cases reported in the literature.
Although lungs were the primary sites of infection in immunocompromised patients, extrapulmonary involvement only was more common in immunocompetent patients (P<0.0001).
Mortality in R.
equi-infected HIV patients was lower in the HAART era (8%) than in pre-HAART era (56%) (P<0.0001), suggesting that HAART improves prognosis in these patients.
Most (85–100%) of clinical isolates were susceptible to vancomycin, clarithromycin, rifampin, aminoglycosides, ciprofloxacin, and imipenem.
Interestingly, there was a marked difference in susceptibility of the isolates to cotrimoxazole between Europe (35/76) and the US (15/15) (P<0.0001).
Empiric treatment of R.
equi infection should include a combination of two antibiotics, preferably selected from vancomycin, imipenem, clarithromycin/azithromycin, ciprofloxacin, rifampin, or cotrimoxazole.
Local antibiograms should be checked prior to using cotrimoxazole due to developing resistance.
American Psychological Association (APA)
Gundelly, Praveen& Suzuki, Yasuhiro& Ribes, Julie A.& Thornton, Alice. 2016. Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097145
Modern Language Association (MLA)
Gundelly, Praveen…[et al.]. Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097145
American Medical Association (AMA)
Gundelly, Praveen& Suzuki, Yasuhiro& Ribes, Julie A.& Thornton, Alice. Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097145