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Information in a Network of Neuronal Cells: Effect of Cell Density and Short-Term Depression
Joint Authors
Di Fabrizio, Enzo
Onesto, Valentina
Amato, Francesco
Cosentino, Carlo
Cesarelli, Mario
Gentile, Francesco
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neurons are specialized, electrically excitable cells which use electrical to chemical signals to transmit and elaborate information.
Understanding how the cooperation of a great many of neurons in a grid may modify and perhaps improve the information quality, in contrast to few neurons in isolation, is critical for the rational design of cell-materials interfaces for applications in regenerative medicine, tissue engineering, and personalized lab-on-a-chips.
In the present paper, we couple an integrate-and-fire model with information theory variables to analyse the extent of information in a network of nerve cells.
We provide an estimate of the information in the network in bits as a function of cell density and short-term depression time.
In the model, neurons are connected through a Delaunay triangulation of not-intersecting edges; in doing so, the number of connecting synapses per neuron is approximately constant to reproduce the early time of network development in planar neural cell cultures.
In simulations where the number of nodes is varied, we observe an optimal value of cell density for which information in the grid is maximized.
In simulations in which the posttransmission latency time is varied, we observe that information increases as the latency time decreases and, for specific configurations of the grid, it is largely enhanced in a resonance effect.
American Psychological Association (APA)
Onesto, Valentina& Cosentino, Carlo& Di Fabrizio, Enzo& Cesarelli, Mario& Amato, Francesco& Gentile, Francesco. 2016. Information in a Network of Neuronal Cells: Effect of Cell Density and Short-Term Depression. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097152
Modern Language Association (MLA)
Onesto, Valentina…[et al.]. Information in a Network of Neuronal Cells: Effect of Cell Density and Short-Term Depression. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097152
American Medical Association (AMA)
Onesto, Valentina& Cosentino, Carlo& Di Fabrizio, Enzo& Cesarelli, Mario& Amato, Francesco& Gentile, Francesco. Information in a Network of Neuronal Cells: Effect of Cell Density and Short-Term Depression. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097152