Daphnetin Protects against Cerebral IschemiaReperfusion Injury in Mice via Inhibition of TLR4NF-κB Signaling Pathway
Joint Authors
Xiong, Xiaoxing
Liu, Jia
Chen, Qianxue
Jian, Zhihong
Shao, Lingmin
Jin, Tong
Zhu, Xiqun
Wang, Lei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Growing evidences indicate that immune-mediated mechanisms contribute to the development of cerebral ischemia/reperfusion (I/R) injury.
Daphnetin (DAP) is a coumarin derivative extracted from Daphne odora var., which displays anti-inflammatory properties.
However, the effect of DAP on cerebral I/R injury is not yet clear.
Recent studies have demonstrated that TLR4/NF-κB signaling pathway takes part in the damaging inflammatory process of cerebral I/R injury.
The present study aimed to investigate the effect of DAP on cerebral I/R injury in vivo and its possible mechanisms.
DAP was administered before middle cerebral artery occlusion and reperfusion in mice.
The neurological scores, cerebral infarct sizes, the levels of inflammatory cytokines, apoptotic neural cells, and the levels of TLR4, NF-κB p65, and IκBα were estimated.
The results showed that an obvious improvement of neurological scores and infarct sizes was observed in DAP-treated mice after MCAO/R.
DAP treatment decreased the overexpression of TNF-α, IL-1β, and IL-6 and attenuated neural cells apoptosis.
Moreover, DAP treatment decreased the TLR4 expression, IκB-α degradation, and nuclear translocation of NF-κB.
Taken together, our results suggested that DAP exerted neuroprotective and anti-inflammatory effects on cerebral I/R injury.
The potential mechanism was involved in the inhibition of TLR4/NF-κB mediated inflammatory signaling pathway.
American Psychological Association (APA)
Liu, Jia& Chen, Qianxue& Jian, Zhihong& Xiong, Xiaoxing& Shao, Lingmin& Jin, Tong…[et al.]. 2016. Daphnetin Protects against Cerebral IschemiaReperfusion Injury in Mice via Inhibition of TLR4NF-κB Signaling Pathway. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097160
Modern Language Association (MLA)
Liu, Jia…[et al.]. Daphnetin Protects against Cerebral IschemiaReperfusion Injury in Mice via Inhibition of TLR4NF-κB Signaling Pathway. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097160
American Medical Association (AMA)
Liu, Jia& Chen, Qianxue& Jian, Zhihong& Xiong, Xiaoxing& Shao, Lingmin& Jin, Tong…[et al.]. Daphnetin Protects against Cerebral IschemiaReperfusion Injury in Mice via Inhibition of TLR4NF-κB Signaling Pathway. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097160