Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis
Joint Authors
Jeung, InCheul
Cheon, Keunyoung
Kim, Mee-Ran
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Endometriosis causes significant chronic pelvic pain, dysmenorrhea, and infertility and affects 10% of all women.
In endometriosis, ectopic endometrium surviving after retrograde menstruation exhibits an abnormal immune response characterized by increased levels of activated macrophages and inflammatory cytokines.
Particularly, dysfunctional natural killer (NK) cells play an important role in the pathogenesis of the disease by either facilitating or inhibiting the survival, implantation, and proliferation of endometrial cells.
NK cells in the peritoneum and peritoneal fluid exhibit reduced levels of cytotoxicity in women with endometriosis.
Several cytokines and inhibitory factors in the serum and peritoneal fluid also dysregulate NK cell cytotoxicity.
Additionally, increased numbers of immature peripheral NK cells and induction of NK cell apoptosis are evident in the peritoneal fluid of women with endometriosis.
The high rate of endometriosis recurrence after pharmaceutical or surgical treatment, which is associated with dysfunctional NK cells, indicates that new immunomodulatory management strategies are required.
A good understanding of immune dysfunction would enable improvement of current treatments for endometriosis.
American Psychological Association (APA)
Jeung, InCheul& Cheon, Keunyoung& Kim, Mee-Ran. 2016. Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097191
Modern Language Association (MLA)
Jeung, InCheul…[et al.]. Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097191
American Medical Association (AMA)
Jeung, InCheul& Cheon, Keunyoung& Kim, Mee-Ran. Decreased Cytotoxicity of Peripheral and Peritoneal Natural Killer Cell in Endometriosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097191