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Carnitine andor Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia
Joint Authors
Maldonado, Cecilia
Fagiolino, Pietro
Queijo, Cecilia
González, Raquel
Vázquez, Marta
Guevara, Natalia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Blood carnitine and/or acetylcarnitine deficiencies are postulated in the literature as possible causes of higher ammonia levels.
The aim of this study was to investigate if the use of valproic acid, the age of the patients, or certain central nervous system pathologies can cause carnitine and/or acetylcarnitine deficiency leading to increased ammonia levels.
Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n=31); (B) with bipolar disorder under valproic acid treatment (n=28); (C) elderly (n=41).
Plasma valproic acid and blood carnitine and acyl carnitine profiles were determined using a validated HPLC and LC-MS/MS method, respectively.
Blood ammonia concentration was determined using an enzymatic automated assay.
Higher ammonia levels were encountered in patients under valproic acid treatment and in the elderly.
This may be due to the lower carnitine and/or acetylcarnitine found in these patients.
Patients with controlled seizures had normal carnitine and acetylcarnitine levels.
Further studies are necessary in order to conclude if the uncontrolled bipolar disorder could be the cause of higher carnitine and/or acetylcarnitine levels.
American Psychological Association (APA)
Maldonado, Cecilia& Guevara, Natalia& Queijo, Cecilia& González, Raquel& Fagiolino, Pietro& Vázquez, Marta. 2016. Carnitine andor Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097193
Modern Language Association (MLA)
Maldonado, Cecilia…[et al.]. Carnitine andor Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097193
American Medical Association (AMA)
Maldonado, Cecilia& Guevara, Natalia& Queijo, Cecilia& González, Raquel& Fagiolino, Pietro& Vázquez, Marta. Carnitine andor Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097193