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Retinal Macroglial Responses in Health and Disease
Joint Authors
de Hoz, Rosa
Rojas, Blanca
Ramirez, Ana I.
Salazar, Juan J.
Triviño, Alberto
Ramirez, José M.
Gallego, Beatriz I.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina.
Astrocytes and Müller cells (retinal macroglia) provide physical support to neurons and supplement them with several metabolites and growth factors.
Macroglia are involved in maintaining the homeostasis of extracellular ions and neurotransmitters, are essential for information processing in neural circuits, participate in retinal glucose metabolism and in removing metabolic waste products, regulate local blood flow, induce the blood-retinal barrier (BRB), play fundamental roles in local immune response, and protect neurons from oxidative damage.
In response to polyetiological insults, glia cells react with a process called reactive gliosis, seeking to maintain retinal homeostasis.
When malfunctioning, macroglial cells can become primary pathogenic elements.
A reactive gliosis has been described in different retinal pathologies, including age-related macular degeneration (AMD), diabetes, glaucoma, retinal detachment, or retinitis pigmentosa.
A better understanding of the dual, neuroprotective, or cytotoxic effect of macroglial involvement in retinal pathologies would help in treating the physiopathology of these diseases.
The extensive participation of the macroglia in retinal diseases points to these cells as innovative targets for new drug therapies.
American Psychological Association (APA)
de Hoz, Rosa& Rojas, Blanca& Ramirez, Ana I.& Salazar, Juan J.& Gallego, Beatriz I.& Triviño, Alberto…[et al.]. 2016. Retinal Macroglial Responses in Health and Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097199
Modern Language Association (MLA)
de Hoz, Rosa…[et al.]. Retinal Macroglial Responses in Health and Disease. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097199
American Medical Association (AMA)
de Hoz, Rosa& Rojas, Blanca& Ramirez, Ana I.& Salazar, Juan J.& Gallego, Beatriz I.& Triviño, Alberto…[et al.]. Retinal Macroglial Responses in Health and Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097199