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Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model
Joint Authors
Song, Liu-nan
Kong, Xiao-dan
Wang, Hong-jiang
Zhan, Li-bin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Development of an animal model of rheumatoid arthritis-interstitial lung disease (RA-ILD) and improved knowledge of the pathogenesis of RA-ILD may facilitate earlier diagnosis and the development of more effective targeted therapies.
Methods.
Adult male Wistar rats were studied in an adjuvant arthritis (AA) model induced by the injection of Freund’s complete adjuvant (FCA).
Rats were sacrificed on days 7, 14, 21, and 28 after FCA injection.
Lung tissue was obtained for histopathological examination and evaluation of Caveolin-1 (Cav-1) and transforming growth factor-β (TGF-β1) protein expression levels.
Results.
Pulmonary inflammation was evident in lung tissue from day 21 after FCA injection.
Inflammation and mild fibrosis were observed in lung tissue on day 28 after FCA injection.
Cav-1 protein expression was significantly decreased from day 7 through day 28 and TGF-β1 protein expression was significantly increased on day 28 after FCA injection compared to control (P<0.05).
Conclusion.
We established an AA rat model that exhibited the extra-articular complication of RA-ILD.
We identified Cav-1 and TGF-β1 as protein biomarkers of RA-ILD in this model and propose their signaling pathway as a possible target for therapeutic intervention.
American Psychological Association (APA)
Song, Liu-nan& Kong, Xiao-dan& Wang, Hong-jiang& Zhan, Li-bin. 2016. Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097201
Modern Language Association (MLA)
Song, Liu-nan…[et al.]. Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097201
American Medical Association (AMA)
Song, Liu-nan& Kong, Xiao-dan& Wang, Hong-jiang& Zhan, Li-bin. Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097201