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Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development
Joint Authors
Zheng, Yang
Wang, Xiaoming
Zhao, Xuna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
This study aims to evaluate the process of brain development in neonates using combined amide proton transfer (APT) imaging and conventional magnetization transfer (MT) imaging.
Materials and Methods.
Case data were reviewed for all patients hospitalized in our institution’s neonatal ward.
Patients underwent APT and MT imaging (a single protocol) immediately following the routine MR examination.
Single-slice APT/MT axial imaging was performed at the level of the basal ganglia.
APT and MT ratio (MTR) measurements were performed in multiple brain regions of interest (ROIs).
Data was statistically analyzed in order to assess for significant differences between the different regions of the brain or correlation with patient gestational age.
Results.
A total of 38 neonates were included in the study, with ages ranging from 27 to 41 weeks’ corrected gestational age.
There were statistically significant differences in both APT and MTR measurements between the frontal lobes, basal ganglia, and occipital lobes (APT: frontal lobe versus occipital lobe P = 0.031 and other groups P = 0.00 ; MTR: frontal lobe versus occipital lobe P = 0.034 and other groups P = 0.00 ).
Furthermore, APT and MTR in above brain regions exhibited positive linear correlations with patient gestational age.
Conclusions.
APT/MT imaging can provide valuable information about the process of the neonatal brain development at the molecular level.
American Psychological Association (APA)
Zheng, Yang& Wang, Xiaoming& Zhao, Xuna. 2016. Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097215
Modern Language Association (MLA)
Zheng, Yang…[et al.]. Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097215
American Medical Association (AMA)
Zheng, Yang& Wang, Xiaoming& Zhao, Xuna. Magnetization Transfer and Amide Proton Transfer MRI of Neonatal Brain Development. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097215