The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population
Joint Authors
Zhou, Dong
Wang, Xinhong
Chen, Tao
Wen, Wen
Liu, Yang
Wu, Yue
Yuan, Zuyi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study is to investigate the potential association of the NLRP3 rs10754558 and CARD8 rs2043211 polymorphisms with the occurrence and prognosis of CAD.
Gene polymorphisms were analyzed using the ABI PRISM-Snapshot multiplex method in 515 CAD patients and 401 control subjects.
The serum level of IL-1β was investigated by ELISA assays.
The clinical endpoints were evaluated during a median follow-up period of 32 months.
The NLRP3 rs10754558 gene polymorphism was significantly associated with the occurrence of CAD, while the CARD8 rs2043211 gene polymorphism was not involved.
Patients carrying G allele of NLRP3 rs10754558 had more severe coronary artery stenosis.
Multivariable analysis revealed a significant association of the G allele with major adverse cardiac event.
The serum IL-1β concentrations in patients with GG genotype were significantly increased compared with those in the patients with CC genotype.
Our findings for the first time show that the NLRP3 rs10754558 polymorphism is involved in the occurrence of CAD in the Chinese Han population; and G allele can effectively predict clinical outcome of CAD.
The G allele susceptibility to CAD is maybe associated with the increased level of serum IL-1β.
American Psychological Association (APA)
Zhou, Dong& Wang, Xinhong& Chen, Tao& Wen, Wen& Liu, Yang& Wu, Yue…[et al.]. 2016. The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097249
Modern Language Association (MLA)
Zhou, Dong…[et al.]. The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097249
American Medical Association (AMA)
Zhou, Dong& Wang, Xinhong& Chen, Tao& Wen, Wen& Liu, Yang& Wu, Yue…[et al.]. The NLRP3 rs10754558 Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097249