Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease
Joint Authors
Panza, Francesco
Imbimbo, Bruno P.
Santamato, Andrea
Greco, Antonio
Lozupone, Madia
Zecca, Chiara
Barulli, Maria Rosaria
Bellomo, Antonello
Pilotto, Alberto
Daniele, Antonio
Logroscino, Giancarlo
Seripa, Davide
Solfrizzi, Vincenzo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The failure of several Phase II/III clinical trials in Alzheimer’s disease (AD) with drugs targeting β-amyloid accumulation in the brain fuelled an increasing interest in alternative treatments against tau pathology, including approaches targeting tau phosphatases/kinases, active and passive immunization, and anti-tau aggregation.
The most advanced tau aggregation inhibitor (TAI) is methylthioninium (MT), a drug existing in equilibrium between a reduced (leuco-methylthioninium) and oxidized form (MT+).
MT chloride (methylene blue) was investigated in a 24-week Phase II clinical trial in 321 patients with mild to moderate AD that failed to show significant positive effects in mild AD patients, although long-term observations (50 weeks) and biomarker studies suggested possible benefit.
The dose of 138 mg/day showed potential benefits on cognitive performance of moderately affected AD patients and cerebral blood flow in mildly affected patients.
Further clinical evidence will come from the large ongoing Phase III trials for the treatment of AD and the behavioral variant of frontotemporal dementia on a new form of this TAI, more bioavailable and less toxic at higher doses, called TRx0237.
More recently, inhibitors of tau acetylation are being actively pursued based on impressive results in animal studies obtained by salsalate, a clinically used derivative of salicylic acid.
American Psychological Association (APA)
Panza, Francesco& Solfrizzi, Vincenzo& Seripa, Davide& Imbimbo, Bruno P.& Lozupone, Madia& Santamato, Andrea…[et al.]. 2016. Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097314
Modern Language Association (MLA)
Panza, Francesco…[et al.]. Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease. BioMed Research International No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1097314
American Medical Association (AMA)
Panza, Francesco& Solfrizzi, Vincenzo& Seripa, Davide& Imbimbo, Bruno P.& Lozupone, Madia& Santamato, Andrea…[et al.]. Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097314