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FSGS Recurrence in Adults after Renal Transplantation
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recurrence of focal segmental glomerulosclerosis (FSGS) in the allograft occurs in 30–50% of patients, and it is associated with poor renal allograft survival.
Major risk factors for recurrence are younger age at diagnosis, rapid progression to end-stage renal disease, white race, and the loss of previous allografts due to recurrence.
Recent data support the hypothesis that circulating permeability factors play a crucial role in podocyte injury and progression of FSGS.
Due to lack of controlled trials, the management of recurrent FSGS is inconsistent and highly empirical.
Prophylactic and perioperative treatment with plasmapheresis and high-dose (intravenous) cyclosporine represent the main cornerstones of immunosuppressive therapy.
In recent years, therapy with rituximab has shown promising results.
Despite evidence of activation of the renin-angiotensin system (RAS) in recurrent FSGS and its association with progression, only limited data exist on the renoprotective role of RAS blockade in this setting.
Further well designed studies are needed on pathogenesis risk factors and therapeutical options in FSGS and its recurrence after transplantation.
American Psychological Association (APA)
Rudnicki, Michael. 2016. FSGS Recurrence in Adults after Renal Transplantation. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097332
Modern Language Association (MLA)
Rudnicki, Michael. FSGS Recurrence in Adults after Renal Transplantation. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097332
American Medical Association (AMA)
Rudnicki, Michael. FSGS Recurrence in Adults after Renal Transplantation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097332