Application of Hydrogel in Reconstruction Surgery: HydrogelFat Graft Complex Filler for Volume Reconstruction in Critical Sized Muscle Defects
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Autogenic fat graft usually suffers from degeneration and volume shrinkage in volume reconstruction applications.
How to maintain graft viability and graft volume is an essential consideration in reconstruction therapies.
In this presented investigation, a new fat graft transplantation method was developed aiming to improve long term graft viability and volume reconstruction effect by incorporation of hydrogel.
The harvested fat graft is dissociated into small fragments and incorporated into a collagen based hydrogel to form a hydrogel/fat graft complex for volume reconstruction purpose.
In vitro results indicate that the collagen based hydrogel can significantly improve the survivability of cells inside isolated graft.
In a 6-month investigation on artificial created defect model, this hydrogel/fat graft complex filler has demonstrated the ability of promoting fat pad formation inside the targeted defect area.
The newly generated fat pad can cover the whole defect and restore its original dimension in 6-month time point.
Compared to simple fat transplantation, this hydrogel/fat graft complex system provides much improvement on long term volume restoration effect against degeneration and volume shrinkage.
One notable effect is that there is continuous proliferation of adipose tissue throughout the 6-month period.
In summary, the hydrogel/fat graft system presented in this investigation demonstrated a better and more significant effect on volume reconstruction in large sized volume defect than simple fat transplantation.
American Psychological Association (APA)
Lui, Y. F.& Ip, W. Y.. 2016. Application of Hydrogel in Reconstruction Surgery: HydrogelFat Graft Complex Filler for Volume Reconstruction in Critical Sized Muscle Defects. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097343
Modern Language Association (MLA)
Lui, Y. F.& Ip, W. Y.. Application of Hydrogel in Reconstruction Surgery: HydrogelFat Graft Complex Filler for Volume Reconstruction in Critical Sized Muscle Defects. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097343
American Medical Association (AMA)
Lui, Y. F.& Ip, W. Y.. Application of Hydrogel in Reconstruction Surgery: HydrogelFat Graft Complex Filler for Volume Reconstruction in Critical Sized Muscle Defects. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097343