Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
Joint Authors
Xanthos, Theodoros
Faa, Armando
Pantazopoulos, Charalampos
Kouskouni, Evangelia
Barouxis, Dimitrios
Vasileiou, Panagiotis
Lelovas, Pavlos
Kotsilianou, Olympia
Pantazopoulos, Ioannis
Garosa, Clara
Kaparos, George
Iacovidou, Nicoletta
Pliatsika, Paraskevi
Gkiokas, Georgios
Papalois, Apostolos E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Purpose.
To investigate the effect of EPO administration on postresuscitation renal function.
Methods.
Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of 19±2 kg were randomly assigned to 2 different groups of 12 subjects each.
After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg.
The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation.
Results.
Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p=0.027).
Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p=0.001).
There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values’ p=0.049, 0.01, and 0.004, resp.).
Conclusions.
Administration of EPO protected swine from postresuscitation acute kidney injury.
American Psychological Association (APA)
Pantazopoulos, Charalampos& Iacovidou, Nicoletta& Kouskouni, Evangelia& Pliatsika, Paraskevi& Papalois, Apostolos E.& Kaparos, George…[et al.]. 2016. Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097364
Modern Language Association (MLA)
Pantazopoulos, Charalampos…[et al.]. Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097364
American Medical Association (AMA)
Pantazopoulos, Charalampos& Iacovidou, Nicoletta& Kouskouni, Evangelia& Pliatsika, Paraskevi& Papalois, Apostolos E.& Kaparos, George…[et al.]. Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097364