Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms
Joint Authors
Lwow, Felicja
Szepietowski, J. C.
Reich, Adam
Heisig, Monika
Łaczmański, Łukasz
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Uremic pruritus (UP) is a frequent and bothersome symptom in hemodialysis patients.
Its etiology is not fully understood and that is why there is no specific treatment.
The endocannabinoid system plays a role in many pathological conditions.
There is reliable evidence on the association between cannabinoid system and pruritus.
In our study, we aimed to evaluate whether genetic variations in the endocannabinoid receptor 1 (CNR1) gene can affect UP.
The rs12720071, rs806368, rs1049353, rs806381, rs10485170, rs6454674, and rs2023239 polymorphisms of the CNR1 gene were genotyped in 159 hemodialysis patients and 150 healthy controls using two multiplex polymerase chain reactions and the minisequencing technique.
No statistically significant relationship was found in any of the evaluated genotypes between patients with and without UP, even after excluding patients with diabetes and dyslipidemia.
There were no differences between patients with UP and the control group.
However, in the group of all HD patients, a significantly higher incidence of GA genotype and lower incidence in GG genotype in the polymorphism rs806381s were revealed versus the control group ( p = 0 .
04 ).
It seems that polymorphisms of the CNR1 gene are not associated with uremic pruritus.
American Psychological Association (APA)
Heisig, Monika& Łaczmański, Łukasz& Reich, Adam& Lwow, Felicja& Szepietowski, J. C.. 2016. Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097365
Modern Language Association (MLA)
Heisig, Monika…[et al.]. Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097365
American Medical Association (AMA)
Heisig, Monika& Łaczmański, Łukasz& Reich, Adam& Lwow, Felicja& Szepietowski, J. C.. Uremic Pruritus Is Not Associated with Endocannabinoid Receptor 1 Gene Polymorphisms. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097365