Comparative Analysis of Human B Cell Epitopes Based on BCG Genomes
Joint Authors
Wan, Kanglin
Zhao, Xiuqin
Li, Machao
Liu, Haican
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Tuberculosis is a huge global health problem.
BCG is the only vaccine used for about 100 years against TB, but the reasons for protection variability in populations remain unclear.
To improve BCG efficacy and develop a strategy for new vaccines, the underlying genetic differences among BCG subtypes should be understood urgently.
Methods and Findings.
Human B cell epitope data were collected from the Immune Epitope Database.
Epitope sequences were mapped with those of 15 genomes, including 13 BCGs, M.
bovis AF2122/97, and M.
tuberculosis H37Rv, to identify epitopes distribution.
Among 398 experimentally verified B cell epitopes, 321 (80.7%) were conserved, while the remaining 77 (19.3%) were lost to varying degrees in BCGs.
The variable protective efficacy of BCGs may result from the degree of B cell epitopes deficiency.
Conclusions.
Here we firstly analyzed the genetic characteristics of BCGs based on B cell epitopes and found that B cell epitopes distribution may contribute to vaccine efficacy.
Restoration of important antigens or effective B cell epitopes in BCG could be a useful strategy for vaccine development.
American Psychological Association (APA)
Li, Machao& Liu, Haican& Zhao, Xiuqin& Wan, Kanglin. 2016. Comparative Analysis of Human B Cell Epitopes Based on BCG Genomes. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097382
Modern Language Association (MLA)
Li, Machao…[et al.]. Comparative Analysis of Human B Cell Epitopes Based on BCG Genomes. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097382
American Medical Association (AMA)
Li, Machao& Liu, Haican& Zhao, Xiuqin& Wan, Kanglin. Comparative Analysis of Human B Cell Epitopes Based on BCG Genomes. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097382