The Modulatory Effect of Ischemia and Reperfusion on Arginine Vasopressin-Induced Arterial Reactions
Joint Authors
Grześk, Grzegorz
Szadujkis-Szadurska, Katarzyna
Malinowski, Bartosz
Piotrowska, Małgorzata
Wiciński, Michał
Gajdus, Marta
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim of the Study.
The purpose of this study was to investigate the impact of ischemia and reperfusion on the resistance of arteries to AVP (arginine vasopressin), with a particular emphasis on the role of smooth muscle cells in the action of vasopressin receptors and the role of the cGMP-associated signalling pathway.
Materials and Methods.
Experiment was performed on the perfunded tail arteries from male Wistar rats.
The constriction triggered by AVP after 30 minutes of ischemia and 30 and 90 minutes of reperfusion was analysed.
Analogous experiments were also carried out in the presence of 8Br-cGMP.
Results.
Ischemia reduces and reperfusion increases in a time-dependent manner the arterial reaction to AVP.
The presence of 8Br-cGMP causes a significant decrease of arterial reactivity under study conditions.
Conclusions.
Ischemia and reperfusion modulate arterial contraction triggered by AVP.
The effect of 8Br-cGMP on reactions, induced by AVP after ischemia and reperfusion, indicates that signalling pathway associated with nitric oxide (NO) and cGMP regulates the tension of the vascular smooth muscle cells.
American Psychological Association (APA)
Szadujkis-Szadurska, Katarzyna& Malinowski, Bartosz& Piotrowska, Małgorzata& Grześk, Grzegorz& Wiciński, Michał& Gajdus, Marta. 2016. The Modulatory Effect of Ischemia and Reperfusion on Arginine Vasopressin-Induced Arterial Reactions. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097401
Modern Language Association (MLA)
Szadujkis-Szadurska, Katarzyna…[et al.]. The Modulatory Effect of Ischemia and Reperfusion on Arginine Vasopressin-Induced Arterial Reactions. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097401
American Medical Association (AMA)
Szadujkis-Szadurska, Katarzyna& Malinowski, Bartosz& Piotrowska, Małgorzata& Grześk, Grzegorz& Wiciński, Michał& Gajdus, Marta. The Modulatory Effect of Ischemia and Reperfusion on Arginine Vasopressin-Induced Arterial Reactions. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097401