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Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli
Joint Authors
al-Agamy, Mohamed H.
El Mahdy, Taghrid S.
Shibl, Atef M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Extended-spectrum β-lactamases (ESβLs) and AmpC β-lactamases cause β-lactam resistance in Escherichia coli.
Fecal colonization by ESβL- and/or AmpC-positive E.
coli is a source of nosocomial infections.
Methods.
In order to investigate inpatient fecal colonization by ESβLs and AmpC, antibiotic sensitivity tests were conducted and minimum inhibitory concentrations (MICs) were determined using the disk diffusion method and E-test, respectively.
Characterization of ESβL and AmpC was performed using E-test strips, and a set of PCRs and DNA sequence analyses were used to characterize the ESβL and AmpC genes.
Results.
The whole collection of E.
coli isolates ( n = 50 ) was sensitive to imipenem, tigecycline, colistin, and fosfomycin, while 26% of the isolates showed reduced susceptibility to ceftazidime (MIC ≥ 4 μg/mL).
ESβL was phenotypically identified in 26% (13/50) of cases, while AmpC activity was detected in two ESβL-producing E.
coli isolates.
All ESβL-producing E.
coli were positive for the CTX-M gene, eleven isolates carried b l a CTX-M-15 , and two isolates carried b l a CTX-M-14 gene.
Two CTX-M-positive E.
coli isolates carried b l a CMY-2 .
Conclusions.
The alimentary tract is a significant reservoir for ESβL- and/or AmpC-producing E.
coli, which may lead to nosocomial infection.
American Psychological Association (APA)
al-Agamy, Mohamed H.& El Mahdy, Taghrid S.& Shibl, Atef M.. 2016. Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097410
Modern Language Association (MLA)
al-Agamy, Mohamed H.…[et al.]. Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097410
American Medical Association (AMA)
al-Agamy, Mohamed H.& El Mahdy, Taghrid S.& Shibl, Atef M.. Fecal Colonization with Extended-Spectrum Beta-Lactamase and AmpC-Producing Escherichia coli. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097410