The Role of 18F-FDG PETCT and MRI in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Song, Shaoli
Liu, Qiufang
Wang, Chen
Li, Panli
Liu, Jianjun
Huang, Gang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
We performed this meta-analysis to determine the utilities of 18F-FDG PET/CT and MRI in assessing the pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in the same cohort of patients with breast cancer.
Methods.
Two reviewers systematically searched on PubMed, Scopus, and Springer (from the beginning of 1992 to Aug.
1, 2015) for the eligible articles.
Heterogeneity, pooled sensitivity and specificity, positive likelihood ratio, negative likelihood ratio, and the summary receiver operating characteristic (SROC) curve were calculated to estimate the diagnostic efficacy of 18F-FDG PET/CT and MRI.
Results.
A total of 6 studies including 382 pathologically confirmed patients were eligible.
The pooled sensitivity and specificity of 18F-FDG PET/CT were 0.86 (95% CI: 0.76–0.93) and 0.72 (95% CI: 0.49–0.87), respectively.
Pooled sensitivity and specificity of MRI were 0.65 (95% CI: 0.45–0.80) and 0.88 (95% CI: 0.75–0.95), respectively.
The area under the SROC curve of 18F-FDG PET/CT and MRI was 0.88 and 0.84, respectively.
Conclusion.
Study indicated that 18F-FDG PET/CT had a higher sensitivity and MRI had a higher specificity in assessing pCR in breast cancer patients.
Therefore, the combined use of these two imaging modalities may have great potential to improve the diagnostic performance in assessing pCR after NAC.
American Psychological Association (APA)
Liu, Qiufang& Wang, Chen& Li, Panli& Liu, Jianjun& Huang, Gang& Song, Shaoli. 2016. The Role of 18F-FDG PETCT and MRI in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097418
Modern Language Association (MLA)
Liu, Qiufang…[et al.]. The Role of 18F-FDG PETCT and MRI in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097418
American Medical Association (AMA)
Liu, Qiufang& Wang, Chen& Li, Panli& Liu, Jianjun& Huang, Gang& Song, Shaoli. The Role of 18F-FDG PETCT and MRI in Assessing Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097418