Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population
Joint Authors
Wang, Xinhong
Yuan, Zuyi
Han, Zhenhua
Dong, Xin
Zhang, Chaoying
Wu, Yue
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Recent genome-wide association studies (GWAS) have indicated an association of histone deacetylase 9 (HDAC9) genetic variant with large-vessel stroke and coronary artery disease, among the European population.
However, whether HDAC9 gene is associated with an increased susceptibility to acute coronary syndrome (ACS) in Chinese Han population is not known.
A total of 472 patients, including patients with ACS ( N = 309 ), and those with chest pain syndrome (controls, N = 163 ) were enrolled.
Genotyping for HDAC9 gene was performed using the ligation detection reaction assay.
A series of statistical analyses were performed to investigate the correlation between HDAC9 gene SNPs and the susceptibility to ACS.
The results revealed a significant association of rs2240419 with ACS risk in which the A allele (P = 0.047) and the A allele carriers (AA + AG) (P = 0.037) were more likely to be in ACS group as compared to those in the control group.
None of two other SNPs, rs2389995 and rs2107595, were significantly associated with ACS risk (P > 0.05).
Logistic regression analyses further revealed an increased risk for ACS in A allele carrier among rs2240419 genotypes, as compared to those with GG homozygotes (odds ratio: 1.869, 95% CI 1.143, 3.056, P = 0.013).
A significant correlation between rs2240419 polymorphism of HDAC9 gene and the susceptibility to ACS in Chinese Han population was observed in this study.
American Psychological Association (APA)
Han, Zhenhua& Dong, Xin& Zhang, Chaoying& Wu, Yue& Yuan, Zuyi& Wang, Xinhong. 2016. Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097419
Modern Language Association (MLA)
Han, Zhenhua…[et al.]. Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097419
American Medical Association (AMA)
Han, Zhenhua& Dong, Xin& Zhang, Chaoying& Wu, Yue& Yuan, Zuyi& Wang, Xinhong. Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097419