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In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats
Joint Authors
Bourget, Jean-Michel
Auger, François A.
Germain, Lucie
Tondreau, Maxime Y.
Laterreur, Véronique
Vallières, Karine
Gauvin, Robert
Tremblay, Catherine
Lacroix, Dan
Ruel, J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
There is a clinical need for tissue-engineered small-diameter (<6 mm) vascular grafts since clinical applications are halted by the limited suitability of autologous or synthetic grafts.
This study uses the self-assembly approach to produce a fibroblast-derived decellularized vascular scaffold (FDVS) that can be available off-the-shelf.
Briefly, extracellular matrix scaffolds were produced using human dermal fibroblasts sheets rolled around a mandrel, maintained in culture to allow for the formation of cohesive and three-dimensional tubular constructs, and decellularized by immersion in deionized water.
The FDVSs were implanted as an aortic interpositional graft in six Sprague-Dawley rats for 6 months.
Five out of the six implants were still patent 6 months after the surgery.
Histological analysis showed the infiltration of cells on both abluminal and luminal sides, and immunofluorescence analysis suggested the formation of neomedia comprised of smooth muscle cells and lined underneath with an endothelium.
Furthermore, to verify the feasibility of producing tissue-engineered blood vessels of clinically relevant length and diameter, scaffolds with a 4.6 mm inner diameter and 17 cm in length were fabricated with success and stored for an extended period of time, while maintaining suitable properties following the storage period.
This novel demonstration of the potential of the FDVS could accelerate the clinical availability of tissue-engineered blood vessels and warrants further preclinical studies.
American Psychological Association (APA)
Tondreau, Maxime Y.& Laterreur, Véronique& Vallières, Karine& Gauvin, Robert& Bourget, Jean-Michel& Tremblay, Catherine…[et al.]. 2016. In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097426
Modern Language Association (MLA)
Tondreau, Maxime Y.…[et al.]. In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097426
American Medical Association (AMA)
Tondreau, Maxime Y.& Laterreur, Véronique& Vallières, Karine& Gauvin, Robert& Bourget, Jean-Michel& Tremblay, Catherine…[et al.]. In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097426