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Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study
Joint Authors
Li, Qince
Zhang, Yue
Zhang, Henggui
Wang, Kuanquan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cardiac conduction disorders are common diseases which cause slow heart rate and syncope.
The best way to treat these diseases by now is to implant electronic pacemakers, which, yet, have many disadvantages, such as the limited battery life and infection.
Biopacemaker has been expected to replace the electronic devices.
Automatic ventricular myocytes (VMs) could show pacemaker activity, which was induced by depressing inward-rectifier K+ current (IK1).
In this study, a 2D model of human biopacemaker was created from the ventricular endocardial myocytes.
We examined the stability of the created biopacemaker and investigated its driving capability by finding the suitable size and spatial distribution of the pacemaker for robust pacing and driving the surrounding quiescent cardiomyocytes.
Our results suggest that the rhythm of the pacemaker is similar to that of the single cell at final stable state.
The driving force of the biopacemaker is closely related to the pattern of spatial distribution of the pacemaker.
American Psychological Association (APA)
Zhang, Yue& Wang, Kuanquan& Li, Qince& Zhang, Henggui. 2016. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097474
Modern Language Association (MLA)
Zhang, Yue…[et al.]. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097474
American Medical Association (AMA)
Zhang, Yue& Wang, Kuanquan& Li, Qince& Zhang, Henggui. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097474