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Synthesis and Antibacterial Activity of Quaternary Ammonium 4-Deoxypyridoxine Derivatives
Joint Authors
Kayumov, Airat R.
Shtyrlin, Nikita V.
Sapozhnikov, Sergey V.
Shtyrlin, Yurii G.
Galiullina, Albina S.
Bondar, Oksana V.
Mirchink, Elena P.
Isakova, Elena B.
Firsov, Alexander A.
Balakin, Konstantin V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A series of novel quaternary ammonium 4-deoxypyridoxine derivatives was synthesized.
Two compounds demonstrated excellent activity against a panel of Gram-positive methicillin-resistant S.
aureus strains with MICs in the range of 0.5–2 μg/mL, exceeding the activity of miramistin.
At the same time, both compounds were inactive against the Gram-negative E.
coli and P.
aeruginosa strains.
Cytotoxicity studies on human skin fibroblasts and embryonic kidney cells demonstrated that the active compounds possessed similar toxicity with benzalkonium chloride but were slightly more toxic than miramistin.
SOS-chromotest in S.
typhimurium showed the lack of DNA-damage activity of both compounds; meanwhile, one compound showed some mutagenic potential in the Ames test.
The obtained results make the described chemotype a promising starting point for the development of new antibacterial therapies.
American Psychological Association (APA)
Shtyrlin, Nikita V.& Sapozhnikov, Sergey V.& Galiullina, Albina S.& Kayumov, Airat R.& Bondar, Oksana V.& Mirchink, Elena P.…[et al.]. 2016. Synthesis and Antibacterial Activity of Quaternary Ammonium 4-Deoxypyridoxine Derivatives. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097484
Modern Language Association (MLA)
Shtyrlin, Nikita V.…[et al.]. Synthesis and Antibacterial Activity of Quaternary Ammonium 4-Deoxypyridoxine Derivatives. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097484
American Medical Association (AMA)
Shtyrlin, Nikita V.& Sapozhnikov, Sergey V.& Galiullina, Albina S.& Kayumov, Airat R.& Bondar, Oksana V.& Mirchink, Elena P.…[et al.]. Synthesis and Antibacterial Activity of Quaternary Ammonium 4-Deoxypyridoxine Derivatives. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097484