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Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations
Joint Authors
Izzo, Francesco
Filice, Salvatore
Cascella, Marco
Cuomo, Arturo
Fusco, Roberta
dell’Aprovitola, Nicoletta
Schiavone, Vincenzo
Granata, Vincenza
Catalano, Orlando
Petrillo, Antonella
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Purpose.
Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions.
Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI.
Material and Methods.
At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist).
Results.
32 acute adverse reactions occurred, accounting for 0.3% of all administration.
Twelve reactions were associated with Gd-DOTA injection (0.11%), 9 with Gd-BOPTA injection (0.08%), 6 with Gd-BTDO3A (0.056%), 3 with Gd-EOB-DTPA (0.028%), and 2 with Gd-DTPA (0.018%).
Twenty-four reactions (75.0%) were mild, four (12.5%) moderate, and four (12.5%) severe.
The most severe reactions were seen associated with use of Gd-BOPTA, with 3 severe reactions in 32 total reactions.
Conclusion.
Acute adverse reactions are generally rare with the overall adverse reaction rate of 0.3%.
The most common adverse reactions were not severe, consisting in skin rash and hives.
American Psychological Association (APA)
Granata, Vincenza& Cascella, Marco& Fusco, Roberta& dell’Aprovitola, Nicoletta& Catalano, Orlando& Filice, Salvatore…[et al.]. 2016. Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097491
Modern Language Association (MLA)
Granata, Vincenza…[et al.]. Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097491
American Medical Association (AMA)
Granata, Vincenza& Cascella, Marco& Fusco, Roberta& dell’Aprovitola, Nicoletta& Catalano, Orlando& Filice, Salvatore…[et al.]. Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097491