Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine
Joint Authors
Zhu, Zhenggang
Xu, Wei
Beeharry, Maneesh K.
Liu, Wentao
Yan, Min
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high.
The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC.
Therefore, the prevalence of advanced gastric cancer (AGC) has prompted the need for aggressive and intensive treatment options.
Among the various treatment options for AGC, surgery is still the mainstay.
However, the efficacy of surgery alone is not established.
Results from multiple randomized controlled trials suggest that preoperative chemotherapy is promising intervention for the treatment and management of AGC.
The main objective of neoadjuvant chemotherapy is to downstage or control micrometastasis in resectable tumor before surgery.
On the other hand, conversion chemotherapy refers to surgical treatment aiming at R0 resection after chemotherapy for originally nonresectable or marginally resectable tumors.
Nevertheless, preoperative chemoradiotherapy is considered beneficial for AGC patients.
Over the last few decades, the combination of chemotherapy and targeted therapy prior to surgery demonstrated great results for the treatment of AGC.
The rapid developments in genomics and proteomics have heralded the era of precision medicine.
The combination of preoperative chemotherapy and precision medicine may enhance survival in AGC patients.
American Psychological Association (APA)
Xu, Wei& Beeharry, Maneesh K.& Liu, Wentao& Yan, Min& Zhu, Zhenggang. 2016. Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097492
Modern Language Association (MLA)
Xu, Wei…[et al.]. Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097492
American Medical Association (AMA)
Xu, Wei& Beeharry, Maneesh K.& Liu, Wentao& Yan, Min& Zhu, Zhenggang. Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097492