Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma
Joint Authors
Kgatle, Mankgopo M.
Setshedi, Mashiko
Hairwadzi, Henry N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a major public health concern and one of the leading causes of tumour-related deaths worldwide.
Extensive evidence endorses that HCC is a multifactorial disease characterised by hepatic cirrhosis mostly associated with chronic inflammation and hepatitis B/C viral infections.
Interaction of viral products with the host cell machinery may lead to increased frequency of genetic and epigenetic aberrations that cause harmful alterations in gene transcription.
This may provide a progressive selective advantage for neoplastic transformation of hepatocytes associated with phenotypic heterogeneity of intratumour HCC cells, thus posing even more challenges in HCC treatment development.
Epigenetic aberrations involving DNA methylation, histone modifications, and noncoding miRNA dysregulation have been shown to be intimately linked with and play a critical role in tumour initiation, progression, and metastases.
The current review focuses on the aberrant hepatoepigenetics events that play important roles in hepatocarcinogenesis and their utilities in the development of HCC therapy.
American Psychological Association (APA)
Kgatle, Mankgopo M.& Setshedi, Mashiko& Hairwadzi, Henry N.. 2016. Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097505
Modern Language Association (MLA)
Kgatle, Mankgopo M.…[et al.]. Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097505
American Medical Association (AMA)
Kgatle, Mankgopo M.& Setshedi, Mashiko& Hairwadzi, Henry N.. Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097505