Developmental Toxicity of Carbon Quantum Dots to the EmbryosLarvae of Rare Minnow (Gobiocypris rarus)
Joint Authors
Xiao, Yuan-Yuan
Liu, Li
Chen, Yao
Zeng, Yu-Lian
Liu, Ming-Zhi
Jin, Li
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The toxic effects of CDs on rare minnow (Gobiocypris rarus) embryos at different developmental stages were investigated.
The results showed that rare minnow embryos had decreased spontaneous movements, body length, increased heart rate, pericardial edema, yolk sac edema, tail/spinal curvature, various morphological malformations, and decreased hatching rate.
Biochemical analysis showed the CDs exposure significantly inhibited the activity of Na+/K+-ATPase and Ca2+-ATPase and increased the MDA contents and the activity of SOD, CAT, and GPX.
Further examination suggested that the CDs exposure induced serious embryonic cellular DNA damage.
Moreover, the CDs exposure induced upregulation of development related genes (Wnt8a and Mstn) along with the downregulation of Vezf1.
Overall, the present study revealed that the CDs exposure has significant development toxicity on rare minnow embryos/larvae.
Mechanistically, this toxicity might result from the pressure of induced oxidative stress coordinate with the dysregulated development related gene expression mediated by the CDs exposure.
American Psychological Association (APA)
Xiao, Yuan-Yuan& Liu, Li& Chen, Yao& Zeng, Yu-Lian& Liu, Ming-Zhi& Jin, Li. 2016. Developmental Toxicity of Carbon Quantum Dots to the EmbryosLarvae of Rare Minnow (Gobiocypris rarus). BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097602
Modern Language Association (MLA)
Xiao, Yuan-Yuan…[et al.]. Developmental Toxicity of Carbon Quantum Dots to the EmbryosLarvae of Rare Minnow (Gobiocypris rarus). BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097602
American Medical Association (AMA)
Xiao, Yuan-Yuan& Liu, Li& Chen, Yao& Zeng, Yu-Lian& Liu, Ming-Zhi& Jin, Li. Developmental Toxicity of Carbon Quantum Dots to the EmbryosLarvae of Rare Minnow (Gobiocypris rarus). BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097602