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The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City
Joint Authors
Liu, Wen-Sheng
Wang, Chiang-Ting
Chen, Tsung-Ming
Mei, Chien-Tai
Chang, Chun-Feng
Liu, Li-Lian
Chiu, Kuo-Hsun
Wu, Tsung-Meng
Lan, Yu-Ching
Chen, Ya-Huey
Lin, Yi-Mei Joy
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bladder cancer is one of the major cancer types and both environmental factors and genetic background play important roles in its pathology.
Kaohsiung is a high industrialized city in Taiwan, and here we focused on this region to evaluate the genetic effects on bladder cancer.
Muscarinic acetylcholine receptor M3 (CHRM3) was reported as a key receptor in different cancer types.
CHRM3 is located at 1q42-43 which was reported to associate with bladder cancer.
Our study attempted to delineate whether genetic variants of CHRM3 contribute to bladder cancer in Chinese Han population in south Taiwan.
Five selected SNPs (rs2165870, rs10802789, rs685550, rs7520974, and rs3738435) were genotyped for 30 bladder cancer patients and 60 control individuals and genetic association studies were performed.
Five haplotypes (GTTAT, ATTGT, GCTAC, ACTAC, and ACCAC) were found significantly associated with low CHRM3 mRNA level and contributed to increased susceptibility of bladder cancer in Kaohsiung city after rigid 10000 consecutive permutation tests.
To our knowledge, this is the first genetic association study that reveals the genetic contribution of CHRM3 gene in bladder cancer etiology.
American Psychological Association (APA)
Wang, Chiang-Ting& Chen, Tsung-Ming& Mei, Chien-Tai& Chang, Chun-Feng& Liu, Li-Lian& Chiu, Kuo-Hsun…[et al.]. 2016. The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097627
Modern Language Association (MLA)
Wang, Chiang-Ting…[et al.]. The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097627
American Medical Association (AMA)
Wang, Chiang-Ting& Chen, Tsung-Ming& Mei, Chien-Tai& Chang, Chun-Feng& Liu, Li-Lian& Chiu, Kuo-Hsun…[et al.]. The Functional Haplotypes of CHRM3 Modulate mRNA Expression and Associate with Bladder Cancer among a Chinese Han Population in Kaohsiung City. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097627