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Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis
Joint Authors
Lv, Xiao-Fei
Wu, Hua-Wang
Tian, Li
Han, Lu-Jun
Li, Jing
Qiu, Ying-Wei
Jiang, Gui-Hua
Zhang, Xue-Lin
Zhang, Rong
Xie, Chuan-Miao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is increasing evidence that cirrhosis may affect functional connectivity among various brain regions in patients prior to onset of overt hepatic encephalopathy (HE).
However, most investigators have focused mainly on alterations in functional connectivity strengths, and the changes in functional connectivity density (FCD) are largely unknown.
Here, we investigated alterations in resting-state FCD in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt HE.
Totally, 31 patients with HBV-RC without overt HE and 30 age- and sex-matched healthy controls underwent resting-state functional MRI examinations.
FCD mapping was employed to compute local and global FCD maps.
Then, short-range and long-range FCD values were calculated and voxel-based comparisons were performed between the two groups.
The HBV-RC group showed significant decreases in FCD, including decreased short-range FCDs in the bilateral middle cingulum gyrus/precuneus, the bilateral cuneus, and the left lingual gyrus/inferior occipital gyrus and decreased long-range FCD in the bilateral cuneus/precuneus.
In addition, the decreased long-range FCD in the bilateral cuneus/precuneus in the HBV-RC group was related to performance on the psychometric hepatic encephalopathy score (PHES) test.
These findings suggest aberrant functional connectivity density in cirrhotic patients prior to overt HE onset, which may provide better insight into understanding the pathophysiological mechanisms underlying the cirrhotic-related cognitive impairment.
American Psychological Association (APA)
Lv, Xiao-Fei& Wu, Hua-Wang& Tian, Li& Han, Lu-Jun& Li, Jing& Qiu, Ying-Wei…[et al.]. 2016. Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097683
Modern Language Association (MLA)
Lv, Xiao-Fei…[et al.]. Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097683
American Medical Association (AMA)
Lv, Xiao-Fei& Wu, Hua-Wang& Tian, Li& Han, Lu-Jun& Li, Jing& Qiu, Ying-Wei…[et al.]. Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097683