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Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients
Joint Authors
Yamanaka, Hisashi
Nanke, Yuki
Yago, Toru
Kawamoto, Manabu
Kobashigawa, Tsuyoshi
Kotake, Shigeru
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone with elevated levels of proinflammatory cytokines.
It has been reported that IL-17 and Th17 cells play important roles in the pathogenesis of RA.
Recently, plasticity in helper T cells has been demonstrated; Th17 cells can convert to Th1 cells.
It remains to be elucidated whether this conversion occurs in the early phase of RA.
Here, we tried to identify Th17 cells, Th1 cells, and Th17 cell-derived Th1 cells (CD161+Th1 cells) in the peripheral blood of early-onset RA patients.
We also evaluated the effect of methotrexate on the ratio of Th17 cells in early-onset RA patients.
The ratio of Th17 cell-derived Th1 cells to CD161+Th17 cells was elevated in the peripheral blood of early-onset RA patients.
In addition, MTX reduced the ratio of Th17 cells but not Th1 cells.
These findings suggest that IL-17 and Th17 play important roles in the early phase of RA; thus, anti-IL-17 antibodies should be administered to patients with RA in the early phase.
American Psychological Association (APA)
Kotake, Shigeru& Nanke, Yuki& Yago, Toru& Kawamoto, Manabu& Kobashigawa, Tsuyoshi& Yamanaka, Hisashi. 2016. Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097688
Modern Language Association (MLA)
Kotake, Shigeru…[et al.]. Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097688
American Medical Association (AMA)
Kotake, Shigeru& Nanke, Yuki& Yago, Toru& Kawamoto, Manabu& Kobashigawa, Tsuyoshi& Yamanaka, Hisashi. Elevated Ratio of Th17 Cell-Derived Th1 Cells (CD161+Th1 Cells) to CD161+Th17 Cells in Peripheral Blood of Early-Onset Rheumatoid Arthritis Patients. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097688