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Enzymatic Synthesis of Sorboyl-Polydatin Prodrug in Biomass-Derived 2-Methyltetrahydrofuran and Antiradical Activity of the Unsaturated Acylated Derivatives
Joint Authors
Wang, Zhaoyu
Bi, Yanhong
Yang, Rongling
Zhao, Xiangjie
Jiang, Ling
Zhu, Chun
Zhao, Yuping
Jia, Jianbo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Efficient and highly regioselective synthesis of the potential 6′′-O-sorboyl-polydatin prodrug in biomass-derived 2-methyltetrahydrofuran (2-MeTHF) was achieved using Candida antarctica lipase B for the first time.
Under the optimal conditions, the initial reaction rate, maximum substrate conversion, and 6′′-regioselectivity were as high as 8.65 mM/h, 100%, and 100%, respectively.
Kinetic and operational stability investigations evidently demonstrated excellent enzyme compatibility of the 2-MeTHF compared to the traditional organic solvents.
With respect to the antioxidant properties, three unsaturated ester derivatives showed slightly lower DPPH radical scavenging activities than the parent agent.
Interestingly, further studies also revealed that the antiradical capacities of the acylates decreased with the elongation of the unsaturated aliphatic chain length from C4 to C11.
The reason might be attributed to the increased steric hindrance derived from the acyl residues in derivatives.
American Psychological Association (APA)
Wang, Zhaoyu& Bi, Yanhong& Yang, Rongling& Zhao, Xiangjie& Jiang, Ling& Zhu, Chun…[et al.]. 2016. Enzymatic Synthesis of Sorboyl-Polydatin Prodrug in Biomass-Derived 2-Methyltetrahydrofuran and Antiradical Activity of the Unsaturated Acylated Derivatives. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097751
Modern Language Association (MLA)
Wang, Zhaoyu…[et al.]. Enzymatic Synthesis of Sorboyl-Polydatin Prodrug in Biomass-Derived 2-Methyltetrahydrofuran and Antiradical Activity of the Unsaturated Acylated Derivatives. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097751
American Medical Association (AMA)
Wang, Zhaoyu& Bi, Yanhong& Yang, Rongling& Zhao, Xiangjie& Jiang, Ling& Zhu, Chun…[et al.]. Enzymatic Synthesis of Sorboyl-Polydatin Prodrug in Biomass-Derived 2-Methyltetrahydrofuran and Antiradical Activity of the Unsaturated Acylated Derivatives. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097751