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Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators
Joint Authors
Javed, Ruheena
Liang, Huiying
Chen, Weidan
Lin, Fangqin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively.
However, because of dearth of biomarkers, it is difficult to quantify the neonatal biological age.
Here we sought to quantify and assess the variability in biological age at birth and to better understand how the aging rates before birth are influenced by exposure in intrauterine period by employing a novel epigenetic biomarker of aging (epigenetic clock).
We observed that the methylation age at birth was independent of the infant’s sex but was significantly influenced by race.
Partial correlation analysis showed a significant negative relationship between maternal socioeconomic status and infants’ methylation age (rs=-0.48, Ps = 0.005).
A significant association with the risk of fast aging was observed for prenatal exposure to tobacco smoke with OR (95% CI) of 3.17 (1.05–9.56).
Both estimated cell abundance measures and lymphocyte subpopulations in cord blood showed that tobacco exposed group exhibit an altered T cell compartment, specifically substantial loss of naive T cells.
Present study provides the first evidence that common perinatal exposure (such as maternal smoking and lower socioeconomic status) may be important aging accelerators and substantial loss of naive T cells may play a role in the smoking-related fast aging phenomenon.
American Psychological Association (APA)
Javed, Ruheena& Chen, Weidan& Lin, Fangqin& Liang, Huiying. 2016. Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097798
Modern Language Association (MLA)
Javed, Ruheena…[et al.]. Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097798
American Medical Association (AMA)
Javed, Ruheena& Chen, Weidan& Lin, Fangqin& Liang, Huiying. Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097798