A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing
Joint Authors
Jinno, Chizuru
Suzuki, Shigehiko
Morimoto, Naoki
Sakamoto, Michiharu
Ito, Ran
Ogino, Shuichi
Taira, Tsuguyoshi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration.
CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing.
In the present study, we evaluated and compared CGSs and conventional CSs.
We prepared 8 mm full-thickness skin defects on the backs of rats.
Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm2 of bFGF solution and implanted into the defects.
At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group ( n = 3 , total n = 24 ).
The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation.
There were no significant differences in the CGS without bFGF and CS groups.
Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF.
The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.
American Psychological Association (APA)
Jinno, Chizuru& Morimoto, Naoki& Ito, Ran& Sakamoto, Michiharu& Ogino, Shuichi& Taira, Tsuguyoshi…[et al.]. 2016. A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097812
Modern Language Association (MLA)
Jinno, Chizuru…[et al.]. A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097812
American Medical Association (AMA)
Jinno, Chizuru& Morimoto, Naoki& Ito, Ran& Sakamoto, Michiharu& Ogino, Shuichi& Taira, Tsuguyoshi…[et al.]. A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097812