Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach
Joint Authors
Zhu, Yujie
Sun, Zhandong
Jiang, Zhi
Jiang, Xiaoqian
Shi, Jingjing
Shen, Bairong
Lin, Yuxin
Yan, Wenying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acute coronary syndrome (ACS) is a life-threatening disease that affects more than half a million people in United States.
We currently lack molecular biomarkers to distinguish the unstable angina (UA) and acute myocardial infarction (AMI), which are the two subtypes of ACS.
MicroRNAs play significant roles in biological processes and serve as good candidates for biomarkers.
In this work, we collected microRNA datasets from the Gene Expression Omnibus database and identified specific microRNAs in different subtypes and universal microRNAs in all subtypes based on our novel network-based bioinformatics approach.
These microRNAs were studied for ACS association by pathway enrichment analysis of their target genes.
AMI and UA were associated with 27 and 26 microRNAs, respectively, nine of them were detected for both AMI and UA, and five from each subtype had been reported previously.
The remaining 22 and 21 microRNAs are novel microRNA biomarkers for AMI and UA, respectively.
The findings are then supported by pathway enrichment analysis of the targets of these microRNAs.
These novel microRNAs deserve further validation and will be helpful for personalized ACS diagnosis.
American Psychological Association (APA)
Zhu, Yujie& Lin, Yuxin& Yan, Wenying& Sun, Zhandong& Jiang, Zhi& Shen, Bairong…[et al.]. 2016. Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097825
Modern Language Association (MLA)
Zhu, Yujie…[et al.]. Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097825
American Medical Association (AMA)
Zhu, Yujie& Lin, Yuxin& Yan, Wenying& Sun, Zhandong& Jiang, Zhi& Shen, Bairong…[et al.]. Novel Biomarker MicroRNAs for Subtyping of Acute Coronary Syndrome: A Bioinformatics Approach. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097825