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Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis
Joint Authors
Fugazza, Alessandro
Gaiani, Federica
Carra, Maria Clotilde
Brunetti, Francesco
Lévy, Michaël
Sobhani, Iradj
Azoulay, Daniel
de’Angelis, Nicola
d'Angelis, Gian Luigi
Catena, Fausto
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Confocal laser endomicroscopy (CLE) is an endoscopic-assisted technique developed to obtain histopathological diagnoses of gastrointestinal and pancreatobiliary diseases in real time.
The objective of this systematic review is to analyze the current literature on CLE and to evaluate the applicability and diagnostic yield of CLE in patients with gastrointestinal and pancreatobiliary diseases.
A literature search was performed on MEDLINE, EMBASE, Scopus, and Cochrane Oral Health Group Specialized Register, using pertinent keywords without time limitations.
Both prospective and retrospective clinical studies that evaluated the sensitivity, specificity, or accuracy of CLE were eligible for inclusion.
Of 662 articles identified, 102 studies were included in the systematic review.
The studies were conducted between 2004 and 2015 in 16 different countries.
CLE demonstrated high sensitivity and specificity in the detection of dysplasia in Barrett’s esophagus, gastric neoplasms and polyps, colorectal cancers in inflammatory bowel disease, malignant pancreatobiliary strictures, and pancreatic cysts.
Although CLE has several promising applications, its use has been limited by its low availability, high cost, and need of specific operator training.
Further clinical trials with a particular focus on cost-effectiveness and medicoeconomic analyses, as well as standardized institutional training, are advocated to implement CLE in routine clinical practice.
American Psychological Association (APA)
Fugazza, Alessandro& Gaiani, Federica& Carra, Maria Clotilde& Brunetti, Francesco& Lévy, Michaël& Sobhani, Iradj…[et al.]. 2016. Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1097846
Modern Language Association (MLA)
Fugazza, Alessandro…[et al.]. Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-31.
https://search.emarefa.net/detail/BIM-1097846
American Medical Association (AMA)
Fugazza, Alessandro& Gaiani, Federica& Carra, Maria Clotilde& Brunetti, Francesco& Lévy, Michaël& Sobhani, Iradj…[et al.]. Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1097846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097846