MicroRNA Expression Signature in Degenerative Aortic Stenosis
Joint Authors
Shi, Jing
Liu, Hui
Wang, Hui
Kong, Xiangqing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Degenerative aortic stenosis, characterized by narrowing of the exit of the left ventricle of the heart, has become the most common valvular heart disease in the elderly.
The aim of this study was to investigate the microRNA (miRNA) signature in degenerative AS.
Through microarray analysis, we identified the miRNA expression signature in the tissue samples from healthy individuals ( n = 4 ) and patients with degenerative AS ( n = 4 ).
Six miRNAs (hsa-miR-193a-3p, hsa-miR-29b-1-5p, hsa-miR-505-5p, hsa-miR-194-5p, hsa-miR-99b-3p, and hsa-miR-200b-3p) were overexpressed and 14 (hsa-miR-3663-3p, hsa-miR-513a-5p, hsa-miR-146b-5p, hsa-miR-1972, hsa-miR-718, hsa-miR-3138, hsa-miR-21-5p, hsa-miR-630, hsa-miR-575, hsa-miR-301a-3p, hsa-miR-636, hsa-miR-34a-3p, hsa-miR-21-3p, and hsa-miR-516a-5p) were downregulated in aortic tissue from AS patients.
GeneSpring 13.1 was used to identify potential human miRNA target genes by comparing a 3-way comparison of predictions from TargetScan, PITA, and microRNAorg databases.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to identify potential pathways and functional annotations associated with AS.
Twenty miRNAs were significantly differentially expressed between patients with AS samples and normal controls and identified potential miRNA targets and molecular pathways associated with this morbidity.
This study describes the miRNA expression signature in degenerative AS and provides an improved understanding of the molecular pathobiology of this disease.
American Psychological Association (APA)
Shi, Jing& Liu, Hui& Wang, Hui& Kong, Xiangqing. 2016. MicroRNA Expression Signature in Degenerative Aortic Stenosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097872
Modern Language Association (MLA)
Shi, Jing…[et al.]. MicroRNA Expression Signature in Degenerative Aortic Stenosis. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097872
American Medical Association (AMA)
Shi, Jing& Liu, Hui& Wang, Hui& Kong, Xiangqing. MicroRNA Expression Signature in Degenerative Aortic Stenosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097872