Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma
Joint Authors
Liu, Bin
Pan, Chun-Feng
He, Zhi-Cheng
Wang, Jun
Wang, Peng-Li
Ma, Teng
Xia, Yang
Chen, Yi-Jiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression.
It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer.
This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression.
RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors.
lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression.
Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/β-catenin pathway in part.
Our study suggests that lncRNA-LET exhibits an important tumor-suppressive effect on LAC progression by inhibiting EMT and Wnt/β-catenin pathway, which provides potential therapeutic targets for LAC.
American Psychological Association (APA)
Liu, Bin& Pan, Chun-Feng& He, Zhi-Cheng& Wang, Jun& Wang, Peng-Li& Ma, Teng…[et al.]. 2016. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097873
Modern Language Association (MLA)
Liu, Bin…[et al.]. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097873
American Medical Association (AMA)
Liu, Bin& Pan, Chun-Feng& He, Zhi-Cheng& Wang, Jun& Wang, Peng-Li& Ma, Teng…[et al.]. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097873