Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma

Abstract EN

Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression.

It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer.

This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression.

RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors.

lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression.

Besides, lncRNA-LET inhibited EMT and negatively regulated Wnt/β-catenin pathway in part.

Our study suggests that lncRNA-LET exhibits an important tumor-suppressive effect on LAC progression by inhibiting EMT and Wnt/β-catenin pathway, which provides potential therapeutic targets for LAC.