Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers
Joint Authors
Neureiter, Daniel
Mayr, Christian
Beyreis, Marlena
Wagner, Andrej
Pichler, Martin
Kiesslich, Tobias
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Biliary tract cancer (BTC) is still a fatal disease with very poor prognosis.
The lack of reliable biomarkers for early diagnosis and of effective therapeutic targets is a major demanding problem in diagnosis and management of BTC.
Due to the clinically silent and asymptomatic characteristics of the tumor, most patients are diagnosed at an already advanced stage allowing only for a palliative therapeutic approach.
MicroRNAs are small noncoding RNAs well known to regulate various cellular functions and pathologic events including the formation and progression of cancer.
Over the last years, several studies have shed light on the role of microRNAs in BTC, making them potentially attractive therapeutic targets and candidates as biomarkers.
In this review, we will focus on the role of oncogenic and tumor suppressor microRNAs and their direct targets in BTC.
Furthermore, we summarize and discuss data that evaluate the diagnostic power of deregulated microRNAs as possible future biomarkers for BTC.
American Psychological Association (APA)
Mayr, Christian& Beyreis, Marlena& Wagner, Andrej& Pichler, Martin& Neureiter, Daniel& Kiesslich, Tobias. 2016. Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers. BioMed Research International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097894
Modern Language Association (MLA)
Mayr, Christian…[et al.]. Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers. BioMed Research International No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1097894
American Medical Association (AMA)
Mayr, Christian& Beyreis, Marlena& Wagner, Andrej& Pichler, Martin& Neureiter, Daniel& Kiesslich, Tobias. Deregulated MicroRNAs in Biliary Tract Cancer: Functional Targets and Potential Biomarkers. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097894