Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice
Joint Authors
Guan, Guiping
Peng, Hanhui
Wang, Hongbing
Li, Guanya
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The purpose of this study was to explore relationships between low dose dietary supplementation with chitosan (COS) and body weight, feed intake, intestinal barrier function, and permeability in mice.
Twenty mice were randomly assigned to receive an unadulterated control diet (control group) or a dietary supplementation with 30 mg/kg dose of chitosan (COS group) for two weeks.
Whilst no significant differences were found between the conditions for body weight or food and water intake, mice in the COS group had an increased serum D-lactate content ( P < 0.05 ) and a decreased jejunal diamine oxidase (DAO) activity ( P < 0.05 ).
Furthermore, mice in COS group displayed a reduced expression of occludin and ZO-1 ( P < 0.05 ) and a reduced expression of occludin in the ileum ( P < 0.05 ).
The conclusion drawn from these findings showed that although 30 mg/kg COS-supplemented diet had no effect on body weight or feed intake in mice, this dosage may compromise intestinal barrier function and permeability.
This research will contribute to the guidance on COS supplements.
American Psychological Association (APA)
Guan, Guiping& Wang, Hongbing& Peng, Hanhui& Li, Guanya. 2016. Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097904
Modern Language Association (MLA)
Guan, Guiping…[et al.]. Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097904
American Medical Association (AMA)
Guan, Guiping& Wang, Hongbing& Peng, Hanhui& Li, Guanya. Low Dosage of Chitosan Supplementation Improves Intestinal Permeability and Impairs Barrier Function in Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097904