Strongyloides stercoralis Infection in Alcoholic Patients
Joint Authors
Teixeira, Marcia C. A.
Pacheco, Flavia T. F.
Souza, Joelma N.
Silva, Mônica L. S.
Inês, Elizabete J.
Soares, Neci M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The course of Strongyloides stercoralis infection is usually asymptomatic with a low discharge of rhabditoid larva in feces.
However, the deleterious effects of alcohol consumption seem to enhance the susceptibility to infection, as shown by a fivefold higher strongyloidiasis frequency in alcoholics than in nonalcoholics.
Moreover, the association between S.
stercoralis infection and alcoholism presents a risk for hyperinfection and severe strongyloidiasis.
There are several possible mechanisms for the disruption of the host-parasite equilibrium in ethanol-addicted patients with chronic strongyloidiasis.
One explanation is that chronic ethanol intake stimulates the hypothalamic-pituitary-adrenal (HPA) axis to produce excessive levels of endogenous cortisol, which in turn can lead to a deficiency in type 2 T helper cells (Th2) protective response, and also to mimic the parasite hormone ecdysone, which promotes the transformation of rhabditiform larvae to filariform larvae, leading to autoinfection.
Therefore, when untreated, alcoholic patients are continuously infected by this autoinfection mechanism.
Thus, the early diagnosis of strongyloidiasis and treatment can prevent serious forms of hyperinfection in ethanol abusers.
American Psychological Association (APA)
Teixeira, Marcia C. A.& Pacheco, Flavia T. F.& Souza, Joelma N.& Silva, Mônica L. S.& Inês, Elizabete J.& Soares, Neci M.. 2016. Strongyloides stercoralis Infection in Alcoholic Patients. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097928
Modern Language Association (MLA)
Teixeira, Marcia C. A.…[et al.]. Strongyloides stercoralis Infection in Alcoholic Patients. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097928
American Medical Association (AMA)
Teixeira, Marcia C. A.& Pacheco, Flavia T. F.& Souza, Joelma N.& Silva, Mônica L. S.& Inês, Elizabete J.& Soares, Neci M.. Strongyloides stercoralis Infection in Alcoholic Patients. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097928