The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases
Joint Authors
Zhang, Peiwei
Zhang, Qing
Cai, Yu-Dong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nowadays, pollution levels are rapidly increasing all over the world.
One of the most important pollutants is PM2.5.
It is known that the pollution environment may cause several problems, such as greenhouse effect and acid rain.
Among them, the most important problem is that pollutants can induce a number of serious diseases.
Some studies have reported that PM2.5 is an important etiologic factor for lung cancer.
In this study, we extensively investigate the associations between PM2.5 and 22 disease classes recommended by Goh et al., such as respiratory diseases, cardiovascular diseases, and gastrointestinal diseases.
The protein-protein interactions were used to measure the linkage between disease genes and genes that have been reported to be modulated by PM2.5.
The results suggest that some diseases, such as diseases related to ear, nose, and throat and gastrointestinal, nutritional, renal, and cardiovascular diseases, are influenced by PM2.5 and some evidences were provided to confirm our results.
For example, a total of 18 genes related to cardiovascular diseases are identified to be closely related to PM2.5, and cardiovascular disease relevant gene DSP is significantly related to PM2.5 gene JUP.
American Psychological Association (APA)
Zhang, Qing& Zhang, Peiwei& Cai, Yu-Dong. 2016. The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097934
Modern Language Association (MLA)
Zhang, Qing…[et al.]. The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097934
American Medical Association (AMA)
Zhang, Qing& Zhang, Peiwei& Cai, Yu-Dong. The Use of Protein-Protein Interactions for the Analysis of the Associations between PM2.5 and Some Diseases. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097934