A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs
Joint Authors
Prada, Justina
Silva-Carvalho, Ricardo
Pires, Isabel
Bianchini, Rodolfo
Jensen-Jarolim, Erika
Queiroga, Felisbina L.
Carvalho, Maria Isabel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Infiltrating cells of the immune system are widely accepted to be generic constituents of tumor microenvironment.
It has been well established that the development of mammary cancer, both in humans and in dogs, is associated with alterations in numbers and functions of immune cells at the sites of tumor progression.
These tumor infiltrating immune cells seem to exhibit exclusive phenotypic and functional characteristics and mammary cancer cells can take advantage of signaling molecules released by them.
Cancer related inflammation has an important role in mammary carcinogenesis, contributing to the acquisition of core hallmark capabilities that allow cancer cells to survive, proliferate, and disseminate.
Indeed, recent studies in human breast cancer and in canine mammary tumors have identified a growing list of signaling molecules released by inflammatory cells that serve as effectors of their tumor-promoting actions.
These include the COX-2, the tumor EGF, the angiogenic VEGF, other proangiogenic factors, and a large variety of chemokines and cytokines that amplify the inflammatory state.
This review describes the intertwined signaling pathways shared by T-lymphocytic/macrophage infiltrates and important tissue biomarkers in both human and dog mammary carcinogenesis.
American Psychological Association (APA)
Carvalho, Maria Isabel& Silva-Carvalho, Ricardo& Pires, Isabel& Prada, Justina& Bianchini, Rodolfo& Jensen-Jarolim, Erika…[et al.]. 2016. A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097940
Modern Language Association (MLA)
Carvalho, Maria Isabel…[et al.]. A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097940
American Medical Association (AMA)
Carvalho, Maria Isabel& Silva-Carvalho, Ricardo& Pires, Isabel& Prada, Justina& Bianchini, Rodolfo& Jensen-Jarolim, Erika…[et al.]. A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097940